Endocrine Abstracts

Aim: Obesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Bariatric surgery (BS) is an effective means of weight reduction in severely obese patients and correlates with improvements in neurocognition. The mechanisms underlying these improvements are not fully elucidated.Material and Methods: Prospective, observational study, including consecutive patients that ...

Metabolic syndrome and insulin resistance persist 5 years after remission of Cushing’s syndrome (CS). Adiponectin and visfatin are two adipokines highly expressed in adipose tissue. Adiponectin is reduced in obesity and insulin-resistant states; visfatin has been shown in some studies to be reduced in obesity. The aim was to evaluate visfatin and adiponectin levels, body composition, insulin resistance and prevalence of metabolic syndrome in a cohort of women with long-te...

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

Chronic exposure to hypercortisolism significantly impacts on patient’s health and health-related quality of life (HRQoL). We developed a disease-generated questio-nnaire to evaluate HRQoL in Cushing’s syndrome (CS) (CushingQoL); in 125 (104 females) patients recruited in Spain, France, Germany, The Netherlands and Italy, clinical and hormonal data were collected and correlated with results of the generic SF-36 questionnaire, a question on self-perceived general heal...

High dose and long-term glucocorticoid (GC) therapy reduce bone mass and negatively affect the metabolic profile. Patients in remission after successful treatment of Cushing’s syndrome (CS) often present hypoadrenalism and require long-term GC replacement.Objective: To evaluate the effect of GC therapy on bone and metabolic parameters in women after long-term remission of CS. Materials and methods: Thirty-two women (mean age: 50±14 years) with ...

Chronic exposure to hypercortisolism has a significant impact on patient’s health and Health-Related Quality of Life (HRQoL), as demonstrated with generic questionnaires. Objective: Develop and validate a disease-generated questionnaire to evaluate HRQoL in patients with Cushing’s syndrome-CS- (Cushing QoL). Methods: After a literature review, interviews with expert endocrinologists and 10 patients identified HRQoL domains and clinical aspects of the disease; an anal...